Immunological Studies of Human Monoamine Oxidases

Publisher Website
Google Scholar
Abstract
Antisera were raised against monoamine oxidase preparations from human placenta and platelets. These antisera were employed to characterize membrane-bound enzyme from a variety of human sources including liver, heart and brain. The comparisons were based on a displacement radioimmunoassay system with soluble placental monoamine oxidase, previous labeled specifically with [3H]pargyline, as antigen. All forms of enzyme investigated demonstrated immunological cross reaction; the placental enzyme appeared to have determinants not exhibited by the enzyme from the platelets or other tissues examined.