Cholinergic Compounds. XIV.1: Synthesis ofcis-2-methyl-5-dimethylaminomethyl-1,3-oxa thiolane methiodide
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 10 (10) , 725-732
- https://doi.org/10.1080/00397918008061836
Abstract
In order to get information about the role of the oxygen atom in position 1 of dioxolane I and thus about the corresponding binding site of the muscarinic receptor, Elferink and Salemink2 have synthesized the sulfur analog II as a cis/trans mixture in a 4:1 or 8:1 ratio, depending upon the synthetic method. This compound proved to be very active as muscarinic agent and might provide useful tool in Structure-Activity Relationship (SAR) studies on muscarinic receptor, if it were available as a pure cis form3.Keywords
This publication has 3 references indexed in Scilit:
- Aminocyclopropyl sulfoxides. Preparation and reaction with acidsJournal of the American Chemical Society, 1976
- Lanthanide shift reagents for nuclear magnetic resonance spectroscopyChemical Reviews, 1973
- Solvent Effects in NMR Spectroscopy. The Geometry of Solute/Solvent Collision ComplexesTetrahedron Letters, 1968