Protein folding in the cell
- 1 January 1992
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 355 (6355) , 33-45
- https://doi.org/10.1038/355033a0
Abstract
In the cell, as in vitro, the final conformation of a protein is determined by its amino-acid sequence. But whereas some isolated proteins can be denatured and refolded in vitro in the absence of other macromolecular cellular components, folding and assembly of polypeptides in vivo involves other proteins, many of which belong to families that have been highly conserved during evolution.Keywords
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