Atypical isolate of Cryptococcus neoformans cultured from sputum of a patient with pulmonary cancer and blastomycosis

Abstract
C. neoformans was isolated repeatedly from a patient with epidermoid carcinoma and pulmonary blastomycosis. The isolate was atypical in that it had only a minute capsule, caused persistent infection but no perceptible disease in mice and initially appeared not to assimilate trehalose. Only after an incubation of 2-3 wk did utilization of this substrate become apparent.