Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation
Top Cited Papers
- 18 March 2002
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 30 (4) , 363-364
- https://doi.org/10.1038/ng865
Abstract
Micro RNAs are a large family of noncoding RNAs of 21–22 nucleotides whose functions are generally unknown. Here a large subset of Drosophila micro RNAs is shown to be perfectly complementary to several classes of sequence motif previously demonstrated to mediate negative post-transcriptional regulation. These findings suggest a more general role for micro RNAs in gene regulation through the formation of RNA duplexes.Keywords
This publication has 15 references indexed in Scilit:
- microRNAsCell, 2001
- An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegansScience, 2001
- An Extensive Class of Small RNAs in Caenorhabditis elegansScience, 2001
- Identification of Novel Genes Coding for Small Expressed RNAsScience, 2001
- The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegansNature, 2000
- Regulation of Drosophila Neurogenesis byRNA:RNA Duplexes?Cell, 1998
- The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNACell, 1997
- A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.Genes & Development, 1996
- The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Cell, 1993
- Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegansCell, 1993