Optimized Procedures for One-Pot Conversion of Alkyl Bromides into Amines via the Staudinger Reaction
- 1 January 1992
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1992 (11) , 1063-1065
- https://doi.org/10.1055/s-1992-26300
Abstract
New optimized procedures for transforming primary and secondary alkyl bromides into the corresponding primary amine salts have been elaborated. Essential modifications of azidation and deprotection of intermediate triethoxyphosphine alkylimides resulted in substantial improvement of the overall yields. Conversion of ammonium tosylates and hydrochlorides into free amines in a non-aqueous medium is described.Keywords
This publication has 0 references indexed in Scilit: