PHENELZINE IN URINE: ASSAY AND RELATION TO ACETYLATOR STATUS
Open Access
- 1 August 1976
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 3 (4) , 633-637
- https://doi.org/10.1111/j.1365-2125.1976.tb04887.x
Abstract
1 Phenelzine cannot be extracted as such from biological fluids. 2 Formation of the acetonide derivative prior to extraction allows phenelzine to be extracted and assayed by gas chromatography at levels down to 0.5 μg/ml. 3 At this sensitivity the drug can be detected in urine but not in plasma, after therapeutic doses. 4 Persons typed as slow acetylators of sulphadimidine excreted approximately twice as much unmetabolized phenelzine in urine compared to fast acetylators.Keywords
This publication has 6 references indexed in Scilit:
- Determination of acetylator status in uraemia [letter].Published by Wiley ,1975
- ACETYLATOR STATUS AND RESPONSE TO PHENELZINE IN DEPRESSED PATIENTSThe Lancet, 1973
- An improved and simplified method of detecting the acetylator phenotype.Journal of Medical Genetics, 1969
- The influence of acetylator phenotype on the effects of treating depression with phenelzineClinical Pharmacology & Therapeutics, 1965
- Clinical Trial of the Treatment of Depressive IllnessBMJ, 1965
- Genetic Control of Isoniazid Metabolism in ManBMJ, 1960