The Biologic Activity of a Potent Analogue of Gonadotropin-Releasing Hormone in Normal and Hypogonadotropic Men
- 8 May 1980
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 302 (19) , 1052-1057
- https://doi.org/10.1056/nejm198005083021903
Abstract
We studied the biologic activity of a long-acting analogue of luteinizing hormone-releasing hormone, D-Trp6-Pro9-NEt-LHRH (LHRHa), in five normal men and four hypogonadotropic men previously unresponsive to natural LHRH. All subjects responded to LHRAa, but there were quantitative and qualitative differences between the normal and hypogonadotropic men. Normal men showed a linear dose-response relation, endogenous gonadal steroid secretion, and an adult pattern of gonadotropin secretion characterized by a high ratio of luteinizing hormone (LH) to follicle-stimulating hormone (FSH). Hypogonadotropic men had improving pituitary responses to each dose of LHRHa (priming response), no demonstrable gonadal steroid secretion, and a prepubertal pattern of gonadotropin release characterized by reversal of the normal ratio of LH to FSH. When compared with native LHRH, LHRHa had an augmented ability to discharge gonadotropins acutely and to sustain their release in normal and hypogonadotropic men.Keywords
This publication has 29 references indexed in Scilit:
- Pharmacology of Thyrotropin Releasing Factor (TRF), Luteinizing Hormone Releasing Factor (LRF), and SomatostatinPublished by Springer Nature ,1977
- Effects of Luteinizing Hormone Releasing Hormone (LHRH) upon Bioactive and Immunoreactive Serum LH Levels in Normal SubjectsJournal of Clinical Endocrinology & Metabolism, 1976
- Gonadotropin Determinations in Timed 3-Hour Urine Collections During the Menstrual Cycle and LHRH TestingJournal of Clinical Endocrinology & Metabolism, 1976
- Serum LH and FSH Responses to the Repetitive Administration of Gonadotropin-Releasing Hormone in Patients with Idiopathic Hypogonadotropic HypogonadismJournal of Clinical Endocrinology & Metabolism, 1975
- Comparison of Short and Long-Term Treatment with Synthetic LH-Releasing Hormone and Clomiphene Citrate in Male Hypothalamic HypogonadismJournal of Clinical Endocrinology & Metabolism, 1975
- Effect of Prolonged LH-Releasing Hormone Administration on Gonadotropin Response in Patients with Hypothalamic and Pituitary TumorsJournal of Clinical Endocrinology & Metabolism, 1975
- Restoration of Normal Pituitary Gonadotropin Reserve by Administration of Luteinizing-Hormone-Releasing Hormone in Patients with Hypogonadotropic HypogonadismNew England Journal of Medicine, 1975
- Two Pools of Luteinizing Hormone in the Human Pituitary: Evidence from Constant Administration of Luteinizing Hormone-Releasing HormoneJournal of Clinical Endocrinology & Metabolism, 1974
- Pituitary-testicular responsiveness in male hypogonadotropic hypogonadism.Journal of Clinical Investigation, 1974
- The Male Factor in Fertility and InfertilityFertility and Sterility, 1950