Lower Risk of Postinfarct Rupture in Mouse Heart Overexpressing β2-Adrenergic Receptors: Importance of Collagen Content
- 1 October 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 40 (4) , 632-640
- https://doi.org/10.1097/00005344-200210000-00018
Abstract
This paper addresses whether the enhanced left ventricular (LV) contractility and heart rate, seen in transgenic mice overexpressing β2-adrenergic receptor in the heart, might raise the incidence of LV rupture after myocardial infarct. Transgenic and wild-type mice underwent left coronary artery occlusion. Postinfarct deaths that occurred 1–7 days after surgery were analyzed. Hemodynamics, morphologic parameters, and collagen content in the LV were determined. A significantly lower incidence of LV rupture was observed in transgenic than in wild-type mice 3–5 days after myocardial infarct (2.5 versus 19.7%, pKeywords
This publication has 25 references indexed in Scilit:
- Left ventricular free wall rupture: clinical presentation and managementHeart, 2000
- Serial echocardiographic assessment of left ventricular dimensions and function after myocardial infarction in miceCardiovascular Research, 2000
- Fatal cardiac rupture among patients treated with thrombolytic agents and adjunctive thrombin antagonists: Observations from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction 9 StudyJournal of the American College of Cardiology, 1999
- Collagen Scar Formation After Acute Myocardial InfarctionCirculation, 1997
- Rate of Collagen Deposition During Healing and Ventricular Remodeling After Myocardial Infarction in Rat and Dog ModelsCirculation, 1996
- Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic ReceptorScience, 1994
- Diagnosis of subacute ventricular wall rupture after acute myocardial infarction: Sensitivity and specificity of clinical, hemodynamic and echocardiographic criteriaJournal of the American College of Cardiology, 1992
- Role of collagen in acute myocardial infarct expansion.Circulation, 1991
- Collagen degradation in ischaemic rat heartsBiochemical Journal, 1990
- Frequency of rupture of the left ventricular free wall or ventricular septum among necropsy cases of fatal acute myocardial infarction since introduction of coronary care unitsThe American Journal of Cardiology, 1989