Cognitive fluctuations associated with on‐off phenomenon in Parkinson disease

Abstract
We studied a patient with severe on-off phenomena that complicated chronic L-dopa treatment of Parkinson disease. Neuropsychologic testing was performed in both the on and the off states. Compared with the profound changes in motor status, the neuropsychologic alterations were modest: general disinhibition of language, worsened memory, and perseveration.

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