Leucocyte Function in a Case of Chronic Benign Neutropenia of Infancy Associated with Circulating Leucoagglutinins

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Abstract
A case of [human] chronic benign neutropenia is described in association with circulating leukoagglutinins. Ig[immunoglobulin]G and IgM leukoagglutinins demonstrated by Sephadex G-200 chromatography agglutinated neutrophils and monocyte enriched leukocyte preparations. Total IgG, IgA, IgM, IgE, total hemolytic complement and the 3rd and 4th complement components were all within normal limits. Lymphocyte populations and transformation were normal apart from a relative increase in the number of bone marrow-derived lymphocytes. In vitro studies showed that the patient''s monocytes responded in chemotaxis, phagocytosis and intracellular killing of Staphylococcus aureus in a comparable fashion to that of control neutrophils. Although the patient''s serum also agglutinated monocytes, leukoagglutinins may have etiological significance in this disease. The versatility of the monocyte in benign neutropenia is emphasized.

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