Metabolism of Ba140 In Man

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Abstract
The metabolism of Ba140 has been studied in seven subjects with normal skeletal metabolism and in one subject with vitamin D resistant rickets by serial sampling of serum, urine and stools over a 7 to 14 day period following parenteral administration of Ba140 (half life 12.8 days). The values of the accretion rate of bone salt calculated from Ba140 data were higher than those calculated from Ca45 data under the same experimental conditions. In the case with vitamin D resistant rickets the accretion rate of hone salt as calculated from the Ba140 data was probably normal. After treatment with massive doses of vitamin D the accretion rate rose to values significantly higher than normal. Since there seems to be no fundamental difference in the metabolism of Ba140 and Ca140, Ba140 should be suitable for use as an indicator of skeletal metabolism in humans.