Effect of Fluconazole on the Pharmacokinetics of Doxorubicin in Nonhuman Primates
- 1 April 2000
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 44 (4) , 1100-1101
- https://doi.org/10.1128/aac.44.4.1100-1101.2000
Abstract
Antifungal prophylaxis in cancer patients who are undergoing chemotherapy is associated with prolonged neutropenia. We measured the effect of fluconazole on doxorubicin pharmacokinetics in nonhuman primates to determine if neutropenia is related to a pharmacokinetic interaction that delays the clearance of the chemotherapeutic agent. Fluconazole pretreatment had no effect on doxorubicin pharmacokinetics.Keywords
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