Influence of an Inhibitor of 17α-Hydroxylation on the Biosynthesis of Testosterone by Testicular Tissue
- 1 November 1963
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 73 (5) , 547-553
- https://doi.org/10.1210/endo-73-5-547
Abstract
The compound 3-(6-chloro- 3-methyl,2-indenyl)-pyridine (SU-8000) inhibits the biosynthesis of testosterone by rabbit and dog testis in vitro. In the rabbit the inhibition observed could be accounted for by a specific effect upon 17α-hydroxylation, while in the dog SU-8000 appears to act at more than one point in the biosynthetic pathway to testosterone.Keywords
This publication has 5 references indexed in Scilit:
- The action of gonadotropic hormones upon rabbit testis in vitroBiochimica et Biophysica Acta, 1962
- Inhibitors of Adrenal Corticosteroid 17α-HydroxylationEndocrinology, 1962
- BIOGENESIS OF ESTROGENS BY HUMAN OVARY .4. FORMATION OF NEUTRAL STEROID INTERMEDIATES1961
- PROGESTERONE AS A PRECURSOR OF TESTICULAR ANDROGENSJournal of Biological Chemistry, 1956
- IDENTIFICATION OF CORTICOSTEROIDS OF BEEF ADRENAL EXTRACT BY PAPER CHROMATOGRAPHYJournal of Biological Chemistry, 1951