Establishment of the interferon-mediated antiviral state: role of fatty acid cyclooxygenase.

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Abstract
Inhibitors of fatty acid cyclooxygenase (8,11,14-icosatrienoate, hydrogen donor:oxygen oxidoreductase, EC 1.14.99.1) suppress the establishment of the interferon-mediated antiviral state. The prevention, by these compounds, of the development of interferon protection correlated with the degree and the duration of cyclooxygenase inhibition. Anti-inflammatory substances lacking cyclooxygenase inhibitory activity did not interfere with the establishment of interferon protection. The addition of exogenous prostaglandins did not replace the need for a functional cyclooxygenase and, in some instances, could diminish the establishment of interferon protection. It is proposed that fatty acid cyclooxygenase is an essential component in the optimal induction of the interferon antiviral state.
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