Brief Communication: Antigenic Changes Associated With Resistance to Methotrexate and 6-Mercaptopurine in L1210 Ascites Lymphoma 2
- 1 March 1974
- journal article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 52 (3) , 997-1003
- https://doi.org/10.1093/jnci/52.3.997
Abstract
Antigenic differences were found between untreated L1210 murine lymphoma and 2 drug-resistant sublines. Tumor lines resistant to methotrexate (MTX) produced significantly longer survival times than did drug-sensitive L1210 tumor when 106 cells were inoculated into untreated (C57BL×DBA)F1 mice, and similar though less significant results were obtained with tumors resistant to 6-mercaptopurine (6-MP). In addition, animals immunized with L1210 drug-sensitive tumor by 10 weekly injections of mitomycin C-inactivated tumor cells showed a substantial degree of immunity when challenged with 106 viable drug-sensitive tumor cells. Challenge with the same number of MTX-resistant or 6-MP-resistant L1210 tumor cells increased only slightly the survival time. These findings suggested that the differences were due to changes in antigenic specificity, associated with the development of resistance to 6-MP and/or MTX.Keywords
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