Retrograde transport in corticospinal neurons after spinal cord transection
- 1 April 1983
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 33 (4) , 478
- https://doi.org/10.1212/wnl.33.4.478
Abstract
Complete spinal cord transection at T-6/T-7 in rats caused a decrease in the number of surviving corticospinal neurons. Cell death began 5 and 10 weeks after cord injury. The number of surviving cells decreased progressively for at least 25 weeks after injury. Surviving cells were identified by their ability to transport horseradish peroxidase (HRP) retrograde from a T-1/T-2 insertion site to cortical cell somas. Therapy aimed at promoting corticospinal tract regeneration must be started early after spinal cord injury.This publication has 6 references indexed in Scilit:
- Axonal Elongation into Peripheral Nervous System "Bridges" After Central Nervous System Injury in Adult RatsScience, 1981
- Reinnervation of peripheral nerve segments implanted into the rat central nervous systemBrain Research, 1980
- Vascular permeability and axonal regeneration in tissues autotransplanted into the brainActa Neuropathologica, 1980
- Cytologic Observations on Axotomized Feline Betz CellsJournal of Neuropathology and Experimental Neurology, 1979
- Ensheathment and myelination of regenerating PNS fibres by transplanted optic nerve gliaNeuroscience Letters, 1978
- Abnormal ultrastructural appearances in axons of feline pericruciate cortex after lateral funiculotomyActa Neuropathologica, 1978