Elevated contents of spermidine and spermine in the erythrocytes of cancer patients
- 1 January 1980
- Vol. 45 (1) , 108-111
- https://doi.org/10.1002/1097-0142(19800101)45:1<108::aid-cncr2820450120>3.0.co;2-w
Abstract
Red blood cells (RBC) from 69 patients with advanced cancer and 37 healthy controls were subjected to polyamine determination by using high-performance liquid chromatography. The polyamine contents in normal human RBC were spermidine 15.04 ± 3.63 nmol and spermine 8.82 ± 3.12 nmol per 1010 RBC. Spermidine and spermine levels in RBC were elevated in patients with cancer (p < 0.005). Serial studies in seven patients with cancer indicated that both polyamines in RBC were reduced after successful surgery. Our data indicate that the determination of polyamine levels in RBC is clinically useful as a marker of disease activity in patients with cancer.This publication has 15 references indexed in Scilit:
- Urinary polyamine levels in patients with gastrointestinal malignancyCancer, 2006
- Sensitive fluorimetric method for the determination of putrescine, spermidine and spermine by high-performance liquid chromatography and its application to human bloodJournal of Chromatography B: Biomedical Sciences and Applications, 1978
- A sensitive fluorometric method for the determination of aliphatic diamines and polyamines in biological materials by high-speed liquid chromatographyAnalytical Biochemistry, 1976
- Distribution of spermidine and spermine in blood from cystic fibrosis patients and control subjectsBlood, 1976
- Urinary polyamine levels in patients with localized malignancyCancer, 1976
- Polyamines as predictors of success and failure in cancer chemotherapyThe Lancet, 1975
- Separation of the Dns derivatives of polyamines and related compounds by thin-layer and high-pressure liquid chromatographyJournal of Chromatography A, 1975
- Determination of polyamines in urineClinica Chimica Acta; International Journal of Clinical Chemistry, 1973
- Identification and quantitation of amines by thin-layer chromatographyJournal of Chromatography A, 1971
- Increased Polyamine Concentrations in the Urine of Human Cancer PatientsNature New Biology, 1971