Electrogenic Na+/HCO3−cotransport in neuroglia
- 1 January 1988
- Vol. 1 (5) , 355-357
- https://doi.org/10.1002/glia.440010508
Abstract
Membrane potential recording from glial cells in Necturus optic nerve in the presence of 2 mM Ba++, which was added to block the K+ conductance, gave the following results. (1) In HCO3−-free, low-Na+ solutions (11% of control; Na+ replaced with N-methyl-D-glucamine), the hyperpolarizing effect of adding 10 mM HCO3− was reduced by approximately 80%.(2) 4-acetamido-4′-isothiocynato-stilbene-2,2′-disulfonic acid (SITS, 0.1 or 1 mM) reduced the effect of HCO3− by at least 50%.(3) In the presence of HCO3−, reduction of Na+ caused a depolarization which was much larger than that observed in nominally HCO3−-free solutions. These observations indicate the presence in the glial membrane of an electrogenic Na+/HCO3− contransporter in which the stoichiometry of HCO3− to Na+ is greater than 1.Keywords
This publication has 8 references indexed in Scilit:
- Effects of bicarbonate on glial cell membrane potential in Necturus optic nerveNeuroscience Letters, 1987
- Anion Transport in AstrocytesaAnnals of the New York Academy of Sciences, 1986
- Intracellular pH Regulation in Epithelial CellsAnnual Review of Physiology, 1986
- Rheogenic sodium-bicarbonate cotransport in the peritubular cell membrane of rat renal proximal tubulePflügers Archiv - European Journal of Physiology, 1985
- Electrogenic sodium-bicarbonate symport in cultured corneal endothelial cellsPflügers Archiv - European Journal of Physiology, 1985
- Intracellular pH regulation in the renal proximal tubule of the salamander. Basolateral HCO3- transport.The Journal of general physiology, 1983
- Physiological properties of glial cells in the central nervous system of amphibia.Journal of Neurophysiology, 1966