Experimental bacterial endocarditis. 3. Production and progress of the disease in rabbits.

  • 1 April 1973
    • journal article
    • Vol. 54  (2) , 142-51
Abstract
A simple and reliable model for endocarditis in rabbits has been studied and standardized. Non-bacterial thrombotic endocarditis was produced on either side of the heart by the presence of a polyethylene catheter. One day later, this was converted into bacterial endocarditis by single intravenous injections of streptococci, staphylococci, Proteus and Candida. No infection resulted from injection of L-forms or virus. Reduction of inoculum size or withdrawal of the catheter reduced the incidence of bacterial endocarditis, but the presence of a catheter in the heart for only a few minutes predisposed to infection. Left-sided Streptococcus viridans infection was uniformly fatal, with average survival of about two weeks. Right-sided infection was not always fatal; approximately 25% of infected vegetations healed spontaneously.