USE OF PIPEROXAN AND REGITINE® AS ROUTINE TESTS IN PATIENTS WITH HYPERTENSION

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Abstract
It is generally recognized that persistent elevation of blood pressure and symptoms of ordinary hypertensive vascular disease or essential hypertension occasionally can be caused by secretion of epinephrine from a pheochromocytoma or a paraganglioma. There can exist associated hypertensive retinitis and cardiac or renal abnormality. This type of hypertension often is not recognized as different from the usual variety of unknown etiology. Discovery of the tumor is imperative since removal will effect cure. Therefore, each patient with hypertension should be tested for circulating epinephrine. Goldenberg, Snyder, and Aranow1 introduced the use of the adrenolytic drug 2-(l-piperidylmethyl)-l, 4-benzodioxan (piperoxan, 933F, or benodaine®),2 which usually causes a characteristic reduction of blood pressure in patbnts with pheochromocytoma. Grimson and associates3 used the adrenolytic and sympatholytic drug 2-(N-p-tolyl-N-[m-hydroxyphenyl]-aminomethyl)-imidazoline hydrochloride (C-7337, or regitine®)4 before and during operation for pheochromocytoma. This study was undertaken to compare effects of

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