Isoxazole derivatives as centrally acting muscle relaxants. I Synthesis and activity of 5-(3-aminopropyl)amino-3-phenylisoxazole derivatives.
- 1 January 1986
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (4) , 1634-1642
- https://doi.org/10.1248/cpb.34.1634
Abstract
A series of 5-amino-3-phenylisoxazole derivatives was synthesized and evaluated as part of a search for new types of centrally acting muscle relaxants. The derivatives with an alkylaminopropyl moiety exhibited muscle relaxant activity comparable to that of tolperisone (1), but this activity was accompanied by strong general central nervous system (CNS) depressant and slight anticonvulsant activities. On the other hand, the derivative with a propanamide moiety exhibited a favorable pharmacological profile for a selective muscle relaxant with little CNS depressant action.This publication has 1 reference indexed in Scilit:
- Observation of animal behavior by revolving activity cage methodFolia Pharmacologica Japonica, 1978