Desloratadine Has No Clinically Relevant Electrocardiographic or Pharmacodynamic Interactions with Ketoconazole
- 1 January 2002
- journal article
- clinical trial
- Published by Springer Nature in Clinical Pharmacokinetics
- Vol. 41 (Supplement) , 37-44
- https://doi.org/10.2165/00003088-200241001-00006
Abstract
Objective: This study was performed to assess the electrocardiographic safety and pharmacokinetics of desloratadine in combination with the CYP3A4 inhibitor ketoconazole. Design:A randomised,...Keywords
This publication has 15 references indexed in Scilit:
- A Pharmacokinetic Profile of Desloratadine in Healthy Adults, Including ElderlyClinical Pharmacokinetics, 2002
- Effect of race and sex on single and multiple dose pharmacokinetics of desloratadine.Clinical Pharmacokinetics, 2002
- Lack of Clinically Relevant Interaction Between Desloratadine and ErythromycinClinical Pharmacokinetics, 2002
- Efficacy and Tolerability of Once-Daily 5mg Desloratadine, an H1-Receptor Antagonist, in Patients with Seasonal Allergic RhinitisClinical Drug Investigation, 2001
- Preclinical Pharmacology of Desloratadine, a Selective and Nonsedating Histamine H1 Receptor Antagonist2nd Communication: Lack of central nervous system and cardiovascular effectsArzneimittelforschung, 2000
- Preclinical Pharmacology of Desloratadine, a Selective and Nonsedating Histamine H1 Receptor AntagonistArzneimittelforschung, 2000
- Arrhythmogenic mechanisms of non‐sedating antihistaminesClinical and Experimental Allergy, 1999
- Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicityClinical and Experimental Allergy, 1999
- Cardiovascular profile of loratadineClinical and Experimental Allergy, 1999
- Blockade of HERG and Kv1.5 by KetoconazoleThe Journal of Pharmacology and Experimental Therapeutics, 1998