GROWTH OF SINCLAIR SWINE MELANOMA IN THE HAMSTER CHEEK POUCH1

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Abstract
Specimens from 7 Sinclair swine melanomas were transplanted to the cheek pouches of Syrian Golden hamsters. The specimens were taken from young swine and were derived from raised tumors that were present at birth or developed after birth from flat melanocytic lesions and from apparently normal skin. All 7 specimens grew in the hamster cheek pouch. One lesion, derived from a 3 day old piglet, exhibited the most aggressive growth in the hamster and was successfully transferred to other hamster cheek pouches. These results confirm the malignancy of Sinclair swine melanoma and indicate that tumors of neonatal swine contain more malignant cells than those of older animals.