Development of the Atherosclerotic Plaque

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Abstract
After one has granted that hyperlipidemia and intimal deposition of lipid are primary factors in atherogenesis, the question remains of how to explain the progression to the fully developed, clinically important plaque. The evidence is reviewed that the medial smooth muscle cell, through its proliferation, migration, synthesis of collagen and other substances, and frequent necrosis may play the central role.

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