Hyperglycemic Properties of Crude Pancreatic Proteins.

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Abstract
The hyperglycemic activity of certain fractions derived from the 15% NaCl supernatant, a by-product of insulin manufacture, was detd. before and after alkaline inactivation of the insulin present in these prepns. Hyperglycemic activity was studied in the rabbits but the results were interpreted only qualitatively, since a satisfactory log dose-response was not obtained. The factor was active whether intraven. or subcut. admd. Repeated subcut. admn. produced hypoglycemia and convulsions in some animals. The factor appeared to be stable in heparinized blood at 37[degree]C for 1 hr.; incubated blood itself produced a delayed hyperglycemic effect when injd. intraven. The factor did not protect mice against insulin-induced convulsions, but did reverse the hypoglycemic effect of insulin in the rabbit.

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