2-Mercaptopropionylglycine Affords Enhanced Radioprotection After a Liposome Encapsulation.
Open Access
- 1 January 1995
- journal article
- Published by Oxford University Press (OUP) in Journal of Radiation Research
- Vol. 36 (1) , 31-37
- https://doi.org/10.1269/jrr.36.31
Abstract
Use of radioprotective drugs in radiotherapy is desirable to protect normal tissues. 2-mercaptopropionylglycine (MPG) has shown promising results in experimental radioprotection. In this report, a liposome drug delivery system for MPG has been used in Swiss albino mice exposed to 1 to 8 Gy whole body Gamma-irradiation to test whether or not this modality enhances the MPG afforded radio-protection. A statistically significant, dose dependent enhancement of protection by liposome encapsulated MPG (LEM) was observed. LEM, as compared to free MPG, improved the viabilities of spleen and bone marrow cells by factors between 1.11 and 2.23 for different doses of radiation.Keywords
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