The Xanthones Gentiacaulein and Gentiakochianin are Responsible for the Vasodilator Action of the Roots ofGentiana kochiana
- 1 August 2003
- journal article
- letter
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 69 (8) , 770-772
- https://doi.org/10.1055/s-2003-42784
Abstract
Gentiana kochiana Perr. et Song. (Gentianaceae), a plant used in the traditional medicine of Tuscany (Italy) as antihypertensive remedy, exerts a vasodilator action on in vitro aortic rings that is probably linked to the blocking of the ryanodine-sensitive Ca++ channels. In the present study, three known xanthones were isolated from the crude methanolic extract of the roots: gentiacaulein, gentiakochianin, and swertiaperennin. The first two showed a vasorelaxing activity in rat aortic preparations, pre-contracted by 3 μM norepinephrine (pIC50 = 5.00 ± 0.032 for gentiacaulein, pIC50 = 4.95 ± 0.068 for gentiakochianin), 20 mM KCl (pIC50 = 4.90 ± 0.15 for gentiacaulein; 4.59 ± 0.069 for gentiakochianin), or 5 mM caffeine; on the contrary, in the same conditions, swertiaperennin did not show any vasodilator effect. In conclusion, gentiacaulein and gentiakochianin seem to be the compounds responsible for the vasorelaxing properties of the crude extract of Gentiana kochiana roots.Keywords
This publication has 0 references indexed in Scilit: