Requirement of Microfilaments in Sorting of Actin Messenger RNA
- 13 September 1991
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 253 (5025) , 1275-1277
- https://doi.org/10.1126/science.1891715
Abstract
Specific messenger RNAs (mRNAs) can be sequestered within distinct cellular locations, but little is known about how this is accomplished. The participation of the three major cellular filaments in the localization of actin mRNA was studied in chicken embryo fibroblasts. Movement of actin mRNA to the cell periphery and maintenance of that regionalization required intact microfilaments (composed of actin) but not microtubules or intermediate filaments. The results presented here suggest that actin-binding proteins may participate in mRNA sorting.Keywords
This publication has 25 references indexed in Scilit:
- Actin mRNA localizes in the absence of protein synthesis.The Journal of cell biology, 1990
- Asymmetric distribution of actin mRNA and cytoskeletal pattern generation in polarized epithelial cellsJournal of Molecular Biology, 1989
- Embryonic MAP2 lacks the cross-linking sidearm sequences and dendritic targeting signal of adult MAP2Nature, 1989
- Translational control and the cytoskeleton in Physarum polycephalumCell Motility, 1987
- Propulsion of organelles isolated from Acanthamoeba along actin filaments by myosin-INature, 1986
- Effect of viral infection on host protein synthesis and mRNA association with the cytoplasmic cytoskeletal structure.The Journal of cell biology, 1985
- Movement of myosin-coated fluorescent beads on actin cables in vitroNature, 1983
- The cytoskeletal framework of sea urchin eggs and embryos: Developmental changes in the association of messenger RNADevelopmental Biology, 1983
- On the association of mRNA with the cytoskeleton in uninfected and adenovirus-infected human KB cellsExperimental Cell Research, 1981
- The cytoskeletal framework and poliovirus metabolismCell, 1979