Sympathetic Coronary Vasoconstriction after Adrenergic Beta Blockade

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Abstract
Sympathetic control of the coronary circulation was studied by eliminating the inotropic and chronotropic effects of sympathetic stimulation with adrenergic beta blockade. A remarkable vasoconstrictor effect of the left sympathetic nerve stimulation was observed after an intracoronary injection of propranolol, while the effect of the right sympathetic nerve stimulation was less prominent. The late increase in coronary flow after the cessation of the stimulation was observed to a lesser extent after the adrenergic beta blockade, while the blood pressure and heart rate remained unchanged. The sympathetic coronary vasoconstriction was almost abolished by adrenergic alpha blockade.
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