Monarthric Arthritis Caused by Metastatic Breast Carcinoma

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Abstract
ALTHOUGH breast carcinoma commonly metastasizes to bone, involvement of the knee is unusual. In his review of metastatic bone disease in patients with breast cancer, Galasko1mentioned no such instance. We report a patient with widespread mammary carcinoma in whom metastatic cancer of the knee was diagnosed by cytologic examination of the synovial fluid. Report of a Case In 1962, a woman, then 44 years old, underwent right radical mastectomy with postoperative irradiation for infiltrating ductal carcinoma with metastases to local lymph nodes. She was free of symptoms for five years. In 1967, chest pain, cough, and hemoptysis led to roentgenographic observation of a solitary coin lesion in the right lower lobe of the lung. The lesion regressed in response to estrogen therapy. In 1971, she felt persistent pain in the left knee. Roentgenographic bone survey and radioisotope bone scan showed no abnormality, and the knee showed only minimal degenerative

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