Postnatal Changes in the Activity Ratio of Specific and Nonspecific Cholinesterases from Neuronal Perikarya

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Abstract
A soluble fraction from rat brain neuronal perikarya contained the specific and nonspecific forms of the enzyme acetylcholinesterase ([acetylcholine acetylhydrolase] EC 3.1.1.7 and [acylcholine acylhydrolase] EC 3.1.1.8, respectively). The ratio of the enzyme activities varied along the course of brain development, the nonspecific form being predominant from 1-15 days of age and the specific one showing the pattern of rising activity from day 15 onward. There may be a relationship between this changing in cholinesterase activities and the establishment of synapses within the rat cerebral cortex.