Tioconazole, a New Broad-Spectrum Antifungal Agent: Preclinical Studies Related to Vaginal Candidiasis

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Abstract
Tioconazole is a new broad-spectrum imidazole antifungal agent with in vitro activity against common yeast pathogens approximately fourfold greater than miconazole. Experimental cream formulations are effective for topical therapy in murine vaginal candidiasis. Systemic exposure to tioconazole following vaginal application is less than that following oral administration. Chronic toxicity studies revealed effects only after oral dosing.

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