NEUROFIBROMATOSIS

29 February 1936

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 106 (9) , 682-683
https://doi.org/10.1001/jama.1936.02770090018005

Abstract

A survey of the literature reveals only a few examples of the effect of pregnancy on neurofibromatosis. Sutton¹reported the case of a woman, aged 38, who noted pedunculated tumors of the skin, which appeared during her first pregnancy and disappeared completely following delivery. The tumors reappeared during a second pregnancy and persisted. The microscopic study of the skin lesions revealed them to be neurofibroma of von Recklinghausen. Recently, cases of preexisting neurofibromatosis that were made worse with the occurrence of pregnancy but showed a remission following delivery are reported by Kushner,²Nishizaki³and Hirsh.³Other accounts in the literature⁴describe easily confused lesions termed "pigmented warts" and "fibroma molluscum gravidarum," which appear during pregnancy and disappear following delivery. During the past three years we have examined fifteen cases of the various types of Recklinghausen's neurofibromatosis. In this group we were impressed by the fact

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