ANIMAL-MODEL FOR THEOPHYLLINE - CIMETIDINE DRUG-INTERACTION

  • 1 December 1985
    • journal article
    • research article
    • Vol. 7  (12) , 627-629
Abstract
Cimetidine (300 mg I.V.) and theophylline (15 mg/kg I.V.) were studied in Beagle dogs for possible drug interaction. The drugs were administered alone and in combination using a crossover design. Although none of the determined pharmacokinetic parameters for theophylline changed significantly in the presence of cimetidine, a trend towards significance was found for the terminal half-life, area under the curve, and mean residence time. The magnitude in changes found in Beagles is representative of the changes reported in man.

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