N-Formimidoyl-thienamycin a novel β-actam: an in-vitro comparison with other β-lactam antibiotics

1 May 1981

journal article
research article
Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy

Vol. 7 (5) , 521-529
https://doi.org/10.1093/jac/7.5.521

Abstract

The in-vitro activities of N-formimidoyl-thienamycin were compared with those of other β-lactam antibiotics. N-formimidoyl-thienamycin was highly active against Enterobacteriaceae (MIC₉₀ 0·5 to 8 mg/1), Pseudomonas aeruginosa (MIC₉₀, 8 mg/1) and Staphylococcus aureus-(MIC₉₀ 0·06 mg/1). Protein binding was low (20% bound) and the composition or pH of media had little effect, pH 7·2 appearing to be optimum. N-Formimidoyl-thienamycin was fairly stable in spiked serum at 37°C (half-life 168 h).

Keywords

ANTIBIOTICS
LACTAMS
STAPHYLOCOCCUS
PROTEIN BINDING
PSEUDOMONAS AERUGINOSA
HALF-LIFE
ENTEROBACTERIACEAE

This publication has 1 reference indexed in Scilit:

In Vitro Activity of Thienamycin
Antimicrobial Agents and Chemotherapy, 1978