Antibiotic therapy of meningitis caused by ampicillin-resistantHaemophilus influenzae in Denmark and Greenland 1981 to 1987

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Abstract
A survey was performed in Denmark and Greenland in order to determine whether the current recommendation of ampicillin (400 mg/kg/day) for initial treatment of purulent meningitis is appropriate. Data obtained 1981–1987 in an ongoing nationwide programme for surveillance of ampicillin-resistantHaemophilus species was analysed, and patient records of 21 cases of meningitis caused by ampicillin-resistantHaemophilus influenzae strains (17 in Denmark, 4 in Greenland) reported in the period 1981–1987 were reviewed. In Denmark the overall rate of ampicillin-resistantHaemophilus influenzae was estimated to be approximately 2% for the study period, and the average rate of resistant isolates from spinal fluid was 5.2% (range 0–12.3 %). The incidence of meningitis caused by ampicillin-resistantHaemophilus influenzae strains remained low in the Danish population (around 0.05/100,000/year) except for a peak in 1985. The overall mortality rate ofHaemophilus influenzae meningitis for the study period was 2.4 %, which was the same as before 1980. In Greenland the actual number of cases of meningitis caused by ampicllin-resistantHaemophilus influenzae was small, but the incidence was at least 40 to 80 times higher than in Denmark with a high mortality rate (50 %). These observations prompted revision of the antibiotic regimen in Greenland, whereas the regimen was considered appropriate in Denmark.