Pathogenesis of Acute Hepatic Encephalopathy

Abstract
Hepatic encephalopathy (HE) is a major neuropsychiatric complication of chronic liver disease. Depending upon the duration and severity of the liver disorder and of the presence of precipitating factors, HE may present as one of two major types. Portal-systemic encephalopathy (PSE) results from portal-systemic shunting of venous blood that arises either spontaneously or due to surgical portacaval anastomosis or transjugular intrahepatic shunts (TIPS) aimed at reducing portal hypertension.

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