Tumor-Virus Relationships in Gross Virus-Induced Mouse Lymphomas2

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Abstract
Virus-induced (C3H), virus-accelerated (AKR), spontaneous (AKR), and cell-passaged (AKR and C3H) Gross lymphomas were compared in AKR/J and C3H/HeJ mice in regard to 1) latent periods of lymphoma post isolation of a cell source for syngeneic cell passage, 2) minimum lethal doses of cells transplanted to syngeneic recipients, and 3) murine leukemia virus measured by a tissue-culture XC-cell assay and a newborn virulence assay. Lymphoma latent periods were decreased when the initial isolation from a virus-induced source was compared to latent periods of the third cell passage in C3H mice (P=0.001) but not in AKR mice (P=0.07). Many generations later, latent periods of Iymphoma remained longer in C3H than AKR transplanted lymphomas. Minimum lethal doses of lymphoma cells did not appear to be related to the source of the transplanted cells. In both AKR and C3H mice, the LD 80–100 (the minimum dose of cells tested resulting in fatal lymphoma in 80–100% of recipients) generally tended to decrease as generations post isolation increased. Virus expression was apparently not related to success of cell transplantation. The XC-cell assay was uniformly positive for all AKR lymphoma lines. It was positive for only a few virus-induced C3H lines and single-cell transplanted lines derived from them. The newborn assay was positive for AKR virus-accelerated lymphomas but weakly positive or negative for long-transplanted or spontaneous AKR lymphomas. It was positive for all C3H virus-induced lines but weakly positive or negative for long-transplanted lines. This independence in the XC-cell and newborn assays is discussed in terms of a 2-virus concept of etiology of lymphoma.

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