A Novel Insulin Delivery Algorithm in Rats With Type 1 Diabetes: The Fading Memory Proportional‐Derivative Method
- 27 July 2005
- journal article
- Published by Wiley in Artificial Organs
- Vol. 29 (8) , 599-607
- https://doi.org/10.1111/j.1525-1594.2005.29096.x
Abstract
Abstract: An algorithm designed to automatically control insulin delivery was tested in rats with Type 1 diabetes. This nonlinear algorithm included a fading memory component of proportional and derivative errors in order to simulate normal insulin secretion. Error‐weighting functions for the proportional and derivative terms were used with a performance index designed for error adaptation. In the first version of the algorithm, the proportional gain was adaptively varied. In the second version, a low rate of basal insulin delivery was adaptively varied. Six 6‐h studies with each version were conducted using frequent blood sampling and intravenous insulin delivery. In Version 2 studies, blood glucose levels during the last two hours were well‐controlled and significantly lower than in Version 1 (118 ± 2.0 vs. 130 ± 2.9 mg/dL). Neither version produced hypoglycemia. Future research using this algorithm needs to focus on automated glucose sensing in combination with insulin delivery.Keywords
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