AN ANIMAL MODEL FOR CORNEAL GRAFT REJECTION IN HIGH-RISK KERATOPLASTY
- 1 July 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 46 (1) , 26-29
- https://doi.org/10.1097/00007890-198807000-00003
Abstract
An animal model for corneal graft rejection is described in which corneal neovascularization is induced prior to keratoplasty. This model closely resembles high-risk human corneal grafting, and relies on rejection being initiated solely by the transplanted corneal tissue. All eleven allografts performed using this model rejected; median time to rejection was 17 days. Two treatment regimens were assessed using this rejection model. Topical cyclosporine produced a significant improvement in graft survival (P=0.0025). When systemic cyclosporine was administered there was a highly significant improvement in graft survival (P=0.0001).This publication has 1 reference indexed in Scilit:
- Suppression of Corneal Allograft Rejection by Cyclosporin AArchives of Ophthalmology (1950), 1981