Free Radical-Induced Double Base Lesions
- 1 January 1995
- journal article
- Published by JSTOR in Radiation Research
- Vol. 141 (1) , 91-4
- https://doi.org/10.2307/3579095
Abstract
Evidence is presented for the formation of products in irradiated dinucleoside monophosphates in which both bases are damaged. The dinucleoside monophosphates d(GpT), d(GpC), d(TpG) and d(CpG) were X-irradiated in oxygenated aqueous solution. Product identification was by NMR spectroscopy. In products containing double base lesions, guanine is converted to 8-hydroxyguanine and the pyrimidine base is degraded to a formamido remnant.Keywords
This publication has 0 references indexed in Scilit: