Uptake of Colloidal Chromic Radiophosphate (P32) by Bone and Gonads

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Abstract
The bone and gonad uptake of radioactivity was studied following intravenous, intramuscular, and intracavitary injections into mice of chromic radio-phosphate colloids of 2 different particle sizes. In Type 1 colloids, the particles were up to 0.3 micron in size; in Type 2 colloids they were up to 2.0 micra. Intravenous and intramuscular injections of Type 1 colloids resulted in a primarily high deposition in bone followed by a considerable decrease in activity. Intracavitary administration presented a different pattern, with a peak at 7 days, possible due to extra-cavitary diffusion. Administration of Type 2 colloid produced a steady increase of bone radioactivity throughout the experiment. Intravenous and intramuscular injections of Type 1 colloids resulted in a high gon-adal uptake the first day, followed by a considerable decrease. With administration of Type 2 colloid the primary incorporation of radioactivity varied only slightly thereafter. After intracavitary injection of 25 uc of Type 1 colloid, the femur radioation dose read 4,495 rads/ gram at the seventh day. On the first day, intravenous administration of this colloid resulted in a testis high dose of 1,311 rads and an intramuscular injection resulted in a high dose of 2,682 rads.

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