Effect of extraction method on the yield of furanocoumarins from fruits of Archangelica officinalis Hoffm.

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Abstract
Optimal conditions for the extraction and analysis of furanocoumarins from fruits of Archangelica officinalis Hoffm. have been determined. The following extraction methods were used: exhaustive extraction in a Soxhlet apparatus, ultrasonication at 25 and 60°C, microwave‐assisted solvent extraction in open and closed systems, and accelerated solvent extraction (ASE). In most cases the yields of furanocoumarins were highest using the ASE method. The effects of extracting solvent, temperature and time of extraction using this method were investigated. The highest yield of furanocoumarins by ASE was obtained with methanol at 100–130°C for 10 min. The extraction yields of furanocoumarins from plant material by ultrasonication at 60°C and microwave‐assisted solvent extraction in an open system were comparable to the extraction yields obtained in the time‐ and solvent‐consuming exhaustive process involving the Soxhlet apparatus. Copyright © 2004 John Wiley & Sons, Ltd.