Determination of salicylic acid and its metabolites in urine by derivative synchronous spectrofluorimetry
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 115 (7) , 1007-1011
- https://doi.org/10.1039/an9901501007
Abstract
The simultaneous determination of salicylic acid in binary and/or ternary mixtures and its two main urinary metabolites is proposed. Mixtures of salicylic, salicyluric and gentisic acids are resolved by synchronous spectrofluorimetry, in combination with first-derivative measurements. The urine is extracted with diethyl ether in acid medium. Salicylic and salicyluric acids are re-extracted into glycine-sodium hydroxide buffer solution of pH 11.6 and determined at that pH, and salicylic and gentisic acids are re-extracted into boric acid-sodium hydroxide buffer solution of pH 8.5 and determined at pH 6.Keywords
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