Can Genes Jump Between Eukaryotic Species?
- 2 July 1982
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 217 (4554) , 42-43
- https://doi.org/10.1126/science.7089540
Abstract
A mutant allele of the chromosomal locus corresponding to the cloned actin gene of the yeast Saccharomyces cerevisiae has been constructed by DNA transformation with a hybrid plasmid which integrates into, and thereby disrupts, the protein-encoding sequences of the gene. In a diploid strain of yeast, disruption of the actin gene on one chromosome results in a mutation that segregates as a recessive lethal tightly linked to a selectable genetic marker on the integrated plasmid. The actin gene, therefore, must encode an essential function for yeast cell growth.Keywords
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