Pulmonary metastasis formation after intravenous tumour cell injection in defibrinogenated rats
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 85 (1) , 83-90
- https://doi.org/10.1007/bf00308133
Abstract
In this study a state of temporary defibrinogenation was induced in rats by Defibrase treatment. It was found that the formation of pulmonary metastases after intravenous tumour cell injection was decreased in defibrinogenated rats. However, defibrinogenation did not influence the effect of trauma and infusion of dextran 1000 on metastasis formation. Both these procedures stimulated the formation of metastases in defibrinogenated rats. These results indicate, that fibrinogen and/or fibrin are of importance for the formation of metastases but that the stimulating effect of trauma and dextran 1000 on metastasis formation is independent of fibrinogen and/or fibrin.This publication has 35 references indexed in Scilit:
- Metastasis Formation after Intravenous Tumour Cell Injection in Thrombocytopenic RatsEuropean Surgical Research, 1976
- Dextrans and the Formation of Pulmonary Metastases after Intravenous Tumour Cell Injection in Rats Non-Sensitive to DextranEuropean Surgical Research, 1975
- Plasma Volume after Dextran Infusion in Rats Sensitive and Non-Sensitive to DextranEuropean Surgical Research, 1975
- Defibrination and metastasis formation: Effects of arvin on experimental metastases in micePublished by Elsevier ,1972
- The proteolytic action of the snake venom enzymes arvin and reptilase on N‐terminal chain‐fragments of human fibrinogenFEBS Letters, 1971
- Crosslinking of human fibrin: Evidence for intermolecular crosslinking involving α‐chainsFEBS Letters, 1971
- Effects of Reptilase‐Induced Intravascular Coagulation in DogsActa Physiologica Scandinavica, 1970
- In Vivo Effect of Reptilase on Fibrinogen Metabolism in DogsScandinavian Journal of Clinical and Laboratory Investigation, 1969
- Platelet fibrinogenJournal of Clinical Pathology, 1965
- On the Significance of the Release of Two Different Peptides from Fibrinogen During Clotting.Acta Chemica Scandinavica, 1958