Sensitization of Influenza Virus A2/Singapore by Antineuraminidase

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Abstract
Influenza virus particles possess two well-known virus-coded surface antigens: the haemagglutinin and the neuraminidase. Both seem to have essential functions in the growth cycle of the virus, haemagglutinin being responsible for the initial union of virus with the cell and neuraminidase being involved in the release of virus progeny from the host cell. Antibodies against purified haemagglutinin neutralize the virus, whereas antineuraminidase antibodies fail to do so (Webster & Laver, 1967). The existence of infectious virus-antibody complexes is now well documented for a variety of viruses (see Majer & Link, 1970). Most of the complexes represent sensitized virus, i.e. can be neutralized by homologous antiglobulin. In this communication we shall present results obtained with antibodies against whole influenza virus particles and with antibodies directed against their subunits.

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