Antibiotic prophylaxis in surgery for head and neck cancer. Comparative study of short and prolonged administration of carbenicilhin

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Abstract
A trial of peroperative prophylaxis with carbenicillin was carried out in 140 patients undergoing surgery for neoplastic head and neck lesions. Wound infections occurred in 9·7% of the patients receiving the short (1 day) prophylaxis and in 5·9% of those receiving the prolonged (4 days) prophylaxis; postoperative pneumonia occurred in 4·2% and 4·4% of the patients respectively. The differences between the two treatment groups are not statistically significant. Gram-negative rods were the micro-organisms more frequently isolated either from colonized or from infected wound. A higher rate of wound colonization by Kiebsiella spp. and a trend to an increased frequency and severity of hypokalemia were observed among patients of the prolonged treatment group.

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