Human T Lymphotropic Virus Type 1 protein Tax reduces histone levels

Open Access

1 January 2008

journal article
Published by Springer Nature in Retrovirology

Vol. 5 (1) , 9
https://doi.org/10.1186/1742-4690-5-9

Abstract

Human T-Lymphotropic Virus Type-1 (HTLV-1) is an oncogenic retrovirus that causes adult T-cell leukemia/lymphoma (ATLL). The virally encoded Tax protein is thought to be necessary and sufficient for T-cell leukemogenesis. Tax promotes inappropriate cellular proliferation, represses multiple DNA repair mechanisms, deregulates cell cycle checkpoints, and induces genomic instability. All of these Tax effects are thought to cooperate in the development of ATLL.

Keywords

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